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Oncogenic RIT1 mutations not only activate canonical RAS/MAPK and PI3K/AKT pathways but also modulate nuclear factor, erythroid 2 like 2 (NRF2) target expression, markedly increasing cellular susceptibility to ferroptosis inducers (33)
Vitamin C is known to regenerate oxidized glutathione to its active form, while vitamin E and selenium act as antioxidants to protect against oxidative stress
However, prolonged release of AMPs by engineered probiotics may kill commensal bacteria and thus may reduce their beneficial effects (Mishra et al
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The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
