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This is due to a favorable electrostatic attraction that induces tight junction opening, resulting in enhanced paracellular transport of ions, macromolecules, and hydrophilic drugs across cell barriers, and importantly, improves the BBB penetration of drug-loaded nanoparticles via adsorptive-mediated endocytosis (Roney et al., 2005

CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine

N., Kulkarni, S., Rao, A

This phenomenon can be explained by compounds that have little to no activity, helping the main active component reach its target through mechanisms of action that complement each other, reverse resistance, improve bioavailability, reduce metabolism and excretion, and modulate side effects (93)

By Chen Y-F, Jowett S, Barton P, Malottki K, Hyde C, Gibbs JSR, et al