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Other investigations documented decreased levels of both IGFs in chronic liver diseases but the positive correlation with Child score was confirmed only for IGF-2 (96)

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Biochim Biophys Acta 1797:113848

A later study using the same genetic approach to clear senescent cells, but this time in naturally aging mice, provided further evidence that removing senescent cells improves healthy aging (44)

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Currently, multiple factors including inflammation, oxidative stress, immune dysfunction, mitochondrial dysfunction, and environmental toxicities have been reported to be involved in psychiatric disorders like ASD [64, 65]