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The overactivation of microglia leads to the release of pro-inflammatory factors such as Interleukin-1 beta (IL-1), Tumor Necrosis Factor-alpha (TNF- ), and Interleukin-6 (IL-6), which directly damage dopaminergic neurons in the substantia nigra pars compacta (SNpc) (McCarty and Lerner, 2020)

Studies have shown that quercetin is a classic activator of the nuclear factor E2-related factor 2 (Nrf2) pathway and can significantly enhance the activity of intracellular antioxidant enzymes (such as superoxide dismutase and catalase) (Wang et al., 2017)

Glucose-lowering effects of orally administered superoxide dismutase in type 2 diabetic model rats

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