glutathione redox status (GSH) cycle in hydroperoxide metabolism. GSSG, Mitochondrial glutathione redox cycle and

Y.ChoiD

References to published literature are provided for educational purposes only

Immunity 26 , 191203 (2007)

Primary research: Mitochondrial dysfunction, Barth syndrome, heart failure, age-related mitochondrial decline Mechanism: Binds cardiolipin in the inner mitochondrial membrane, stabilizing electron transport chain function and reducing reactive oxygen species Regulatory status: FDA-approved (Forzinity) for Barth syndrome

Members of this family were first discovered for their potential of metabolizing an array of toxic exogenous compounds, i.e., xenobiotics via GSH conjugation (Cummins et al., 2011)

doi: 10.3168/jds.2021-21535 519 Olvera-AguirreGMendoza-TacoMMArcos-lvarezDNPieiro-VzquezATMoo-HuchinVMCanul-SolsJRet al