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Johnson EC, Carter EK, Dammer EB, Duong DM, Gerasimov ES, Liu Y, Liu J, Betarbet R, Ping L, Yin L, Serrano GE, Beach TG, Peng J, De Jager PL, Haroutunian V, Zhang B, Gaiteri C, Bennett DA, Gearing M, Wingo TS, Wingo AP, Lah JJ, Levey AI, Seyfried NT

Conversely, it was observed that excessive accumulation of mitochondria Ca 2+ led to mitochondrial rupture and a decline in mitochondrial function in Lysosomal storage-diseases (LSDs) (Cantarero et al., 2021), suggesting that mitochondrial biogenesis can be inhibited as a protective mechanism in cells and tissues when lysosomes are defective (Khalil et al., 2017), indicating that lysosomes and mitochondria are interdependent and coordinate across time and space barriers, to complete complex cell metabolism, signal transduction, and other functions to maintain the homeostasis of the whole cell (Qing-long, 2022)

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Effects of TGF- overexpression via rAAV gene transfer on the early repair processes in an osteochondral defect model in minipigs

Archived from the original on 2020-08-01