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pylori infection, CHAC1 contributes to gastric cell oxidative stress and mutations that could potentially lead to cancer, while in cystic fibrosis, reduced CHAC1 levels contribute to chronic inflammation by impairing the bodys ability to regulate oxidative stress (Wada et al., 2018

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The overproduction of ROS leads to prolonged inflammation, a key factor contributing to tumor immunosuppression

21 identified AIF as a mitochondrial flavoprotein and a mitochondrial effector of apoptotic cell death while looking for molecules that induce noncaspase-dependent apoptosis