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Description

UA activates the inflammatory response of tissue-intrinsic cells indirectly affecting immune cells MSU crystals activate the TLR4/NF-B/NLRP3 signaling pathway in human umbilical vein endothelial cells (HUVECs), leading to the secretion of intercellular cell adhesion molecule-1 (ICAM-1), IL-1, IL-6, and vascular cellular adhesion molecule-1 (VCAM-1)

In the intermediate stage, visual abnormalities may begin to appear, with some patients remaining asymptomatic while others show signs of blurry and distorted vision [21, 22]

Franchini M, Marano G, Cruciani M, Mengoli C, Pati I, Masiello F, et al

AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis

Lipid Nanoparticle Drug Products: Chemistry, Manufacturing, and Control Information (Guidance for Industry) [Google Scholar] 179.EMA Reflection paper on the data requirements for intravenous liposomal products developed with reference to an innovator liposomal product