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Animal studies demonstrate that chronic tesofensine treatment produces sustained weight loss even as tolerance to the hypophagic effect gradually develops, indicating additional factors beyond appetite regulation contribute to maintaining maximal weight loss

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Abstract Human dipeptidyl-peptidase III (hDPP III) is a zinc-dependent hydrolase cleaving dipeptides off the N-termini of various bioactive peptides

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The primary mechanism involves delivery of copper ions to copper-dependent enzymes that are essential for connective tissue repair: lysyl oxidase, which crosslinks collagen and elastin fibers to create structural tensile strength