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Demonstrating biological activity whether administered systemically, locally, orally, or intraperitoneally in pre-clinical models and and by the breadth of its cytoprotective, tissue repair, and angiogenic effects across virtually every organ system examined in the research literature

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TCS extracts alone caused alterations in 52 genes involved in oxidative stress pathways, while exposure to TCS, ICS, and LPG smoke extracts resulted in significant changes in DNA methylation and hydroxymethylation [154]