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The cost of cabotegravir and rilpivirine could be a significant barrier to provision in low- and middle-income countries

It is especially useful in conditions where oral supplementation is not suitable or effective, such as in critically ill patients, ICU cases, severe vomiting, or in patients with poor compliance to oral therapy

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The gut microbiota and its metabolites play a pivotal role in high-altitude adaptation by modulating the host immune system through multiple mechanisms ( 3.2.1 Mitigation of oxidative stress Certain gut microbiota and their metabolites enhance the defense of the gut mucosal barrier by alleviating excessive oxidative stress

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