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Similar findings were noted in KEAP1 f/f /Pten f/f (K1P) mice, in which tumor bearing lungs had significantly diminished lymphoid cells and the infiltrating immune cells disproportionately expressed the PD-L1 immune checkpoint, although these tumors responded well to combination anti-PD1/anti-CTLA4 immunotherapy [71]

doi: 10.1046/j.1365-2125.2001.01305.x [DOI] [PMC free article] [PubMed] [Google Scholar] 87.Yarema M, Chopra P, Sivilotti MLA, et al

This idea stems from the free radical theory of aging, which links ROS damage to growing older

showed that ubiquitin-specific protease 7 (USP7) led to increased TFR1 and ferroptosis in a rat model of myocardial ischemia/reperfusion [77]

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doi: 10.1074/jbc.M111.312694