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GSTM1 and GSTT1 are therefore the final enzymatic line of defense in the 4-OHE2 detoxification pathway the layer that becomes most consequential exactly when upstream clearance by COMT and SULT1A1 is most impaired

In contrast, macrophages expressing the C38S mutant pretreated with LPS/ATP and GYY4137 showed a comparable percentage of cells co-expressing NLRP3 and AS to those in LPS/ATP stimulated macrophages (Fig

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After 12 days, the mice were sacrificed, and the tumor tissues were collected