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Importantly, ZSWIM8 binding appears incompatible with conformations observed for AGO2miRNA complexes not engaged with a TDMD trigger, as the PAZ and N domains would either clash with or fail to contact ZSWIM8 (refs

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Quantitatively, the magnitude of protection (based on the genetic damage index) was calculated to be 5.9953.57% for quinic acid and 4.4948.15% for chlorogenic acid [20]