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In PA, the impaired conversion of propionyl-CoA to methylmalonyl-CoA leads not only to intracellular accumulation of propionyl-CoA but also to metabolites such as 3-OH-isopropionate, glycine, propionylglycine, propionylcarnitine, fatty acids, propionic acid, and 2-methylcitrate

Aside from B7 and CD28, there exist several co-stimulatory or co-inhibitory molecules on the APCs and T cells, which play a role in regulating the activity of APCs and T cells and maintaining the bodys immune homeostasis

Physicians should also use the recommended nonantibiotic topical agents (e.g., retinoids, BPO)

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A meta-analysis containing 21 randomized, double-blind, and placebo-controlled studies in duration from 3 months to 1 year revealed that ALC either restored cognitive dysfunction or slowed cognitive deterioration

Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases