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In mouse murine pro-lymphoid (BaF3) cells with mutated JAK2 displayed significantly enhanced glutaminase metabolism and increased expression of GLS compared to wild-type cells [107]

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These may include injection site discomfort or mild swelling, occasional headache, or mild fatigue, particularly with appropriate dosing and patient preparation including adequate hydration

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When drug-induced liver injury is suspected, the diagnostic approach is determined by the clinical presentation