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Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)

High levels of dopamine metabolism, iron, and calcium, coupled with mitochondrial dysfunction and neuroinflammation, contribute to the excessive production of ROS in the brains of PD patients (183)

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GiacaloneMMartinelliRAbramoARubinoAPavoniVIacconiPet al

However, this study has several limitations that should be considered in future research

Nevertheless, challenges such as low oral bioavailability and restricted CNS penetration necessitate further optimization of pharmacokinetics and the development of formulations