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The TSS region was defined as 250 base pairs around the TSS of the gene promoters, as defined in the ENSEMBL gene annotation for hg38

As the IVD ages, the proteoglycan aggregates undergo degradation and the ratio of proteoglycan aggregates to total proteoglycan declines

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A material may achieve a high purity result while still containing contaminants, inconsistencies, or other quality concerns that are not identified through purity testing alone

Many promising preclinical compounds never enter human trials for this reason