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Both OAT and PYCR1 are markedly elevated in IPF lung tissues and fibroblasts, with their expression levels correlating with deteriorating lung function and poor prognosis [71, 72]

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ABCG2 cysteine residues Cys592 and Cys608 formed intramolecular disulfide bonds, regulating substrate specificity, whereas Cys603 and Cys608 created intermolecular disulfide bonds, determining plasma membrane localization (Wakabayashi et al., 2006)

doi: 10.1371/journal.pmed.0030491 103 SpinelliFRBertiRFarinaGCeccarelliFContiFCrescioliC

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