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Tarin, J

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In aged monkeys, while the density of perforated synapses in the dentate gyrus is preserved in old relative to young monkeys, a reduction in synaptic contacts per axonal bouton was associated with cognitive impairment (Haberman et al., 2011)
Nutrition journal 2011

Encouragingly, this energy dysfunction appears to precede clinical symptoms by many years, underscoring its potential as an early biomarker for disease prediction and intervention (Connolly et al., 2019)

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