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Furthermore, cysteamine has been recognized as an efficient depigmenting agent for melasma treatment (Qiu et al., 2000

however, fertile women trying to conceive are advised to ingest 400 mcg/day of folate (from supplements and/or food) to reduce the risk of birth defects

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doi: 10.1007/s002280050132

Acta Pharmacol Sin 2006;27:146773

Between 2 and 12% of patients receiving high-dose MTX therapy may get acute kidney injury, mostly as a result of crystal nephropathy caused by MTX and its metabolite, 7-OH-MTX