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doi: 10.1007/s00414-017-1648-9 108 SchifanoF

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More recent reviews confirm this evidence gap: while preclinical studies continue to demonstrate antioxidant, anti-inflammatory, and mitochondrial-protective effects of natural compounds, large-scale human trials remain scarce, leaving most claims unverified (Parmar et al., 2025

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For example, exploring how CoQ10 supports energy levels reveals a powerful synergy: while carnitine shuttles the fuel (fatty acids) into the mitochondria, CoQ10 acts as the spark plug within the electron transport chain to convert that fuel into ATP