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doi:10.1016/S0892-0362(99)00069-0 Kim HY, Oh JH (1999) Screening of Korean forest plants for rat lens aldose reductase inhibition

While cytoplasmic targets are hard to reach, proteins in the periplasm are clearly more accessible, as the drug only need to breach the outer membrane

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3.2 Catecholamine-induced structural cardiac injury 3.2.1 Myocardial hypertrophy Many studies have confirmed that sustained activation of the SNS is closely related to cardiac hypertrophy (CH) (215, 216), and that renal denervation of the SN can improve CH (164)