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And in the 80s it increased to every three months, which is still what they use today

Some evidence points toward possible reductions in oxidative stress markers, along with increased antioxidant enzyme activity
This is the most common and potentially dangerous side effect
2.4 Mitochondrial dysfunction in PD Mitochondrial dysfunction is intricately linked to PD etiology and ferroptosis

doi: 10.3390/biomedicines13081807

Stumhofer, J.S