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While medication one day past the BUD may still be effective, you have no way to verify this without laboratory testing

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Separate by at least 12 hours, preferably use on alternate days

OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia 30.7 (2010): 804-814

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