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The widely repeated claim that it is ~ten-million-fold more potent than BDNF is a relative in-vitro spine-counting ratio, not a human effect, and key mechanism papers from the originating lab were retracted in 2025

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B12 supplementation does not enhance metabolic rate or promote fat loss in people with normal B12 status

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10.1016/j.clnu.2020.11.009 184

5 HF Validation for Product Design Changes within the Clinical Timeline Design changes to combination products may require an additional HF validation test, particularly if changes occur after clinical studies or a prior validation test