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This effect was actually noted in a small chart review in humansone of the few uses of BPC-157 that has human evidence at this time [7]

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doi: 10.1002/jemt.10296 25 ChanJKRothJOppenheimJJTraceyKJVoglTFeldmannMet al

292 In addition, intermittent hypoxia induces the sympathetic nervous system to increase vascular resistance, down-regulates expression of the kallikrein-kallistatin vasodilator pathway, and activates the renal renin-angiotensin-aldosterone system to cause vasoconstriction