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Ecotoxicol Environ Saf 205:111175

The exact cause of neuronal cell death in AD has not been fully established but could involve a number of apoptotic, necrotic, pyroptotic, ferropoptotitic and perhaps cuproptotic cell death (Mangalmurti and Lukens, 2022

Peer review Peer review information Communications Biology thanks Seyed Amir Malekpour and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Injury may result from any combination of overuse, biomechanical abnormality, systemic disease, aging, or prior use of certain medications

The strongest human data on GHK-Cu is almost entirely topical, 12-week trials on photoaged skin, wrinkle-volume studies, and gene-expression work going back to Pickarts original research in the 1970s

Ethics declarations All procedures complied with the standards for care and use of animal subjects as stated in the Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Resources, National Academy of Sciences, Bethesda, MD)