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Complete biotransformation and protection from oxidative stress are important to maintaining cellular integrity and tissue health

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Blocking of TNF-alpha, type I interferon and STING signalling as well as reintroduction of wild-type ADA2 protein did not rescue the cell death phenotype in vitro

In addition, oxygen-evoked regulation of HIF-1 and NF-B is closely coupled with the intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation)

Identification of HSP90 inhibitors as a novel class of senolytics