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Among the salient indications, inhaled NO is used for acute pulmonary vasoreactivity testing and severe hypoxia in pulmonary arterial hypertension (PAH), nitrates are used extensively in ischemic heart disease and heart failure, sGC stimulators and activators are used for PAH, and PDE5 inhibitors are used for erectile dysfunction, PAH and benign prostatic hyperplasia

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[513] extensively review the involvement of BBB breakdown and dysfunction in neurological deficits and other pathologies, including chronic conditions (Alzheimer's disease, Parkinsons disease, amyotrophic lateral sclerosis, and multiple sclerosis), as well as acute CNS disorders such as stroke, traumatic brain injury, spinal cord injury, and epilepsy