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Notably, elevated levels of PC have been observed in the prefrontal cortex of patients with bipolar disorder

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Lennon, V.A., Kryzer, T.J., Pittock, S.J., Verkman, A.S

doi: 10.1111/j.1600-079X.2007.00547.x 140

Nigella sativa extract in the treatment of depression and serum brain-derived neurotrophic factor (BDNF) levels

This impaired gut barrier function and microbial imbalance can promote the translocation of bacteria, as well as pro-inflammatory cytokines and endotoxins (e.g., LPS), into systemic circulation [141, 142]