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Cell-programmed nutrient partitioning in the tumour microenvironment

Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein

At the cellular level, dysfunction in lipid storage or metabolism can lead to free fatty acid-induced lipotoxicity, with cascading trauma to cell membranes and other components [6]

nucleatum , which associates with impaired immunotherapy efficacy in both patients with CRC, as well as CRC-bearing mice, modulated immune cell recruitment and impaired anti-tumour immunity through the production of succinic acid in a mouse model of CRC 69