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Acanthosis nigricans (pronounced: ah-kan-THO-sis NY-gruh-kans) is a skin disorder that results in velvety, light-brown-to-black patches or marks that occur in areas of your skin that has folds, including the neck, armpits, groin, and under the breasts

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doi: 10.1016/j.scispo.2016.06.004

Tolerance and dose creep Some long-term users report that a previously effective dose becomes less potent over time
