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This multi-mechanistic effect of LBP in improving DPN (Figure 7) warrants further validation in human studies, as well as subsequent development and integration into DM management strategies

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(vi) comorbid diagnosis: Fragile X syndrome, tuberous sclerosis, phenylketonuria or fetal alcohol syndrome or (vii) acute illness

79 Advantages This drug is very effective in the treatment of absence seizures

The crystal structure of human GPx3 revealed that each subunit contained a selenocysteine (Sec) residue and the active Sec-53 was located in a pocket on the protein surface with Gln-87, Trp-161 and Asn-162 nearby 13 , which formed a catalytic tetrad highly conserved in the selenium-dependent GPx family 14