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These pathological changes indicate that oxidative stress is not merely a biochemical abnormality but a direct driver of structural and functional deterioration in the seminiferous epithelium (43)

In the same cohort, MACE risk was found to be about 30% higher in individuals in the highest versus lowest quartile of choline or betaine plasma concentrations (115)

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In addition, it was earlier discussed that autoantibodies against CRP are elevated in lupus nephritis, in which CRP can be elevated, and also it was found to be colocalized with IgG, C1q, C3c, and dsDNA in electron dense deposits in the glomerular basement membrane/subendothelial space of some patients [699]

doi: 10.3390/ijms23052484 109 ShadfarS.ParakhS.JamaliM