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Description
The absorption of B12 from the diet begins with its release from food sources by gastric acid and pepsin in the stomach, followed by its binding to haptocorrin (HC), which is found in saliva and gastric fluid

Accumulation of -syn as intracellular filamentous aggregates is a pathological feature of both sporadic and familial PD ( DJ-1 is another gene reported to cause a familial early onset PD ( Neuroinflammation Neuronal loss in PD is associated with chronic neuroinflammation, which is controlled primarily by microglia, the major resident immune cells in the brain ( -syn or LRRK2 ( Neuromelanin confers the dark pigmentation that is produced from DA oxidation and is so characteristic of the SNpc appearance

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These signs often develop gradually and can be mistaken for symptoms of stress or overwork

Phase 1 and 2 review of titles and abstracts were conducted by JGS and ABB

2010;5:e11765
