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PGC-1alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein
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In particular, combining 2-OHNA with other NAD + biosynthesis inhibitors like FK866 effectively kills NAPRT-proficient cancer cells resistant to single-agent treatments 217
The subjective reports of people taking opioids for pain relief or recreation (De Quincey, 2000) have been corroborated by findings that rodents will work to obtain an opioid but also to avoid opioid blockade (Mucha & Iversen, 1984)
