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Thats not the case for alkanes (pK a = 50), alkenes (pK a = 42), or ammonium salts (pK a = 10) and many others

[10] Can these capsules be taken with food

[DOI] [PubMed] [Google Scholar] 137.Lucas-Ruiz F., Galindo-Romero C., Albaladejo-Garca V., Vidal-Sanz M., Agudo-Barriuso M

On this page: Drinking alcohol before surgery can be dangerous as it increases the risk of bleeding, complications with anaesthesia, and post-operative infections

This is a strong recommendation based on very low-certainty evidence
De Ricco R., Valensin D., Gaggelli E., and Valensin G., Conformation Propensities of DesAcylGhrelin as Probed by CD and NMR, Peptides 43 (2013): 6267
