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Theophylline is a naturally occurring methylxanthine with multiple mechanisms of action, including: 1) antagonism of adenosine receptors on the cell membrane, 2) inhibition of phosphodiesterases that inactivate cAMP

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Research suggests that a flavonoid glucoside extracted from E

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