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Pigment Cell Melanoma Res

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Beyond, many of the observed changes occurred in patients with BD can be considered as signs of premature aging (telomere length, oxidative stress, inflammation, disruptions on biological clocks, epigenetic aging and mitochondrial dysfunction), as prior works hypothesize that accelerated aging process is potentially implicated in the development and course of BD [52]

[PMC free article] [PubMed] [Google Scholar] Dennert, G

doi: 10.1046/j.1523-1755.1998.00891.x

For example, glutathione becomes rapidly oxidized to glutathione disulfide either by glutathione peroxidase (GPx) or by enzyme-independent chemical reactions [102]