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By implication, the durable efficacy of cancer immunotherapy is limited by factors, both tumor intrinsic and extrinsic, that restrict T-cell migration from the source(s) into the tumor regions (e.g., with deficits in T-cell-attracting chemokines, including CCL5 and CXCL9, -10, and -11/CXCR3 axis) and infiltration posttherapy [168,169,170]

TD aggravates ulcerative colitis in mice, associated with the promoted infiltration of proinflammatory M1 macrophages into colonic lamina propria (188)

Schulte, B

265,266 In addition, Trx and thioredoxin-interacting protein (TXNIP), a negative regulator, constitute a redox-like protein compound (redoxisome) that regulates a variety of redox-sensitive signals and is essential for maintaining the intracellular and extracellular redox balance and monitoring inflammatory responses

Invest Cell Pathol 2(3):195216 Fuchs CD, Trauner M (2022) Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

Moreover, the demonstrated neuroprotective and anti-inflammatory properties offer significant potential for cataract, diabetic retinopathy and glaucoma, conditions characterized by pronounced oxidative damage and inflammation