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More importantly, recent technological advancements have enabled the development of tools to quantify and trace NADPH levels in real-time and across subcellular compartments, thereby providing spatial and temporal information that was previously unavailable with traditional methodologies ( MTHFD family ( To date, NADPH metabolism has been targeted primarily for cancer therapeutics as cancer cells upregulate NADPH synthesis to support their massive antioxidative and anabolic requirements ( Statements Author contributions KKYT: Writing original draft, Writing review & editing

The absolute dosing regardless of body mass likely increased the variability of response within supplementation groups thereby limiting the findings of the present study

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