glutamine glutathione depletion Bioinspired nanocatalytic tumor therapy by simultaneous reactive oxygen species generation enhancement and pathway-mediated Glutamine supplementation reverses manganese neurotoxicity
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Kann O, Huchzermeyer C, Kovcs R, Wirtz S, Schuelke M
D.BlancatoJ
Moreover, silibinin induces programmed cell death in human hepatocarcinoma (Hep G2) cells by promoting the secretion of specific miRNAs ( miR223-3p and miR16-5p ) that potentially target the PTEN/AKT signaling pathway, and enhances the cytotoxic effect of sorafenib through the downregulation of miR-92a [956]
W.JacobsonF
The same underlying detection concept was implemented by Motaghi et al
Research has indicated that the regulatory action of L-citrulline on the protein anabolic metabolism of muscle cells is independent of the insulin and Akt pathways, and it directly regulates muscle protein synthesis in rats via the PI3K/MAPK/4E-BP1 pathway [101] (Figure 4)
