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This could be a partial effect, not a complete one, as the knockdown of Nrf2 has been shown to partly (not completely) abolish the reduction in ROS, nitric oxide, and pro-inflammatory cytokines (TNF-, IL-1, and IL-6) [105]

Nakatani T, Roy G, Fujimoto N, Asahara T, Ito A (2001) Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin

In target tissues, such as the liver and the brain, T 4 (the most abundant circulating thyroid hormone) can be converted to T 3 by selenium-containing enzymes known as iodothyronine deiodinases (DIOs) ( Figure 1

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Thakran, M., Shukla, S., Brajpuriya, R