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The depletion of tryptophan in the TME impairs effector T cell function, while kynurenine degradation products can suppress tumor immunity by inducing the generation of Foxp3+ regulatory T cells (Tregs) (134)
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Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P
Imbard A, Benoist JF, Esse R, Gupta S, Lebon S, de Vriese AS, et al
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