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The lower ratio of SAM:SAH is important in Tauopathies, as there is an indirect relationship between disrupted cellular methylation and hyperphosphorylation of Tau [110]

The UPS plays a pivotal role in the maintenance of protein homeostasis, regulation of the cell cycle and modulation of diverse signaling pathways (107-109)

The Akt/mTOR/HIF1 axis orchestrates this metabolic reprogramming by modulating HIF1 activity and glycolytic enzyme expression (174, 175)

[DOI] [Google Scholar] 60.Ou Y., Buchanan A.M., Witt C.E., Hashemi P

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