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GSH-dependent glyoxalase 1 and 2 mediate the detoxification of 2-oxoaldehydes, such as methylglyoxal, which is an electrophilic by-product of glycolysis that reacts spontaneously with proteins, lipids, and nucleic acids, causing irreversible damage [139]

Adherence to the regimen is encouraged to effectively replete or maintain vitamin levels, but occasional timing adjustments are acceptable

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"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome"