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We recommend 3-4 times

doi: 10.3390/ANTIOX13050579 104

As detailed in Table 1, a meta-analysis performed by Conde-Agudelo et al

Larsson M, Weiss B, Janson S, Sundell J, Bornehag CG

It directly impacts both measured outcomes and dropout rates due to nausea

10.1016/j.ejphar.2015.09.017 49