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Due to the complex interaction of different factors that contribute to an effective immune response, there may be more than one correlate of protection, and the mechanisms of protection during natural infection may differ from those seen after vaccination

Since vitamin B12 is water-soluble, any excess is naturally eliminated by the body, significantly lowering the risk of toxicity

Shaking instead of swirling , mechanical stress breaks the peptide structure

Supplements: Veterinarians may prescribe oral or injectable B12 supplements for dogs with malabsorption disorders such as exocrine pancreatic insufficiency (EPI) or chronic gastrointestinal disease

Therefore, your doctor will probably test your blood levels consistently throughout your treatment, in order to ensure that your vitamin D levels are reaching a normal level and not going above (NIH, 2020)