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[20] [21] In the synthesis of creatine, a high-energy molecule believed to enhance exercise, SAM serves as a methyl donor

Pernicious AnemiaPernicious anemia is a blood disorder in which the body does not make enough red blood cells due to a lack of vitamin B12 in the blood

For instance, in the brain, it has been described that neurons operate in a strong physical and metabolic association with astrocytes and glial cells, and the dysregulation of this cooperation contributes to the development of brain disease ( Unlike other types, human brain organoids are usually generated only from human pluripotent stem cells (both hESCs and hiPSCs), mainly due to the low regenerative capacity of the adult human brain (Tang et al., 2022)